The Acme Corporation is a fictional corporation that exists in the Looney Tunes universe. It appeared most prominently in the Road Runner/Wile E. Coyote cartoons, which made Acme infamous for outlandish and downright dangerous products that failed catastrophically at the worst possible times.

The first appearance of the Acme Corporation was in a Buddy cartoon Buddy's Bug Hunt . It also appeared in the Egghead cartoon Count Me Out in which Egghead purchases a "Learn How To Box" kit from Acme.

The company is never clearly defined, but appears to be a conglomerate which produces everything and anything imaginable (leading to the backronym "American Company Making Everything"), no matter how elaborate or extravagant. An example is the Acme Giant Rubber Band, subtitled "(For Tripping Road Runners)", which would appear to be produced specifically for Wile E. Coyote. Considering how often the Coyote uses new Acme products (despite the failure of all the previous ones), he is perhaps one of Acme's best customers.
The company name is ironic since the word acme actually means the best or pinnacle. Generally, products from the fictional Acme Corporation are very generic and tend to fail -- often in a way that gets the user smashed by hard unyielding rock.